Research

I use mathematics, and machine learning to understand the mechanisms underpinning complex biological systems.

Coming soon! (Under review/In writing)

Foy BH, et al. Characterising inflammatory state and response to cardiac surgery by modeling multivariate trajectories of routine laboratory results.

Foy BH, et al. A mesh-free radial basis function method for simulation of high-dimensional conservation problems.

Foy BH, et al. Analysis of flow-sequencing and ventilation heterogeneity in patients with small airways dysfunction.

Select Publications

Foy BH, et al. Elevated RDW is associated with increased mortality in COVID-19 patients. MedRxiv (2020). 

Foy BH, Brightling CE, Siddiqui S. Proning reduces ventilation heterogeneity in patients with elevated body mass index: Implications for COVID-19 pneumonia management? European Respiratory Journal Open Research (In Press)

Foy BH, et al. Characterising the role of the small airways in asthma using low frequency forced oscillations during tidal breathing. Respiratory Medicine (2020). 

Foy BH, Goncalves B, Higgins J. Unravelling disease pathophysiology with mathematical modeling. Annual Review of Pathology: Mechanisms of Disease (2020).

Foy BH, Li A, McClung J, Ranganath R, Higgins JM. Data-driven physiologic thresholds for iron-deficiency associated with hematologic decline. American Journal of Hematology (2019).

Foy BH, Kay D, Siddiqui S, Paiva M, Verbanck S. Increased ventilation heterogeneity in asthma can be attributed to the proximal bronchioles. European Respiratory Journal (2019).

Cremer S, Schloss MJ, Vinegoni C, Foy BH, et al. Diminished reactive hematopoiesis and cardiac inflammation in a mouse model of recurrent myocardial infarction. Journal of the American College of Cardiology (2020).

Foy BH, Soares M, Bordas R, et al. Lung computational models and the role of the small airways in asthma. American Journal of Respiratory and Critical Care Medicine (2019). 

Foy BH, Kay D. A computationally tractable scheme for simulation of the human pulmonary system. Journal of Computational Physics (2019).

Bell AJ, Foy BH, Richardson M, et al. Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma. Journal of Allergy and Clinical Immunology (2019).

Whitfield C, Foy B, Kay D, Jensen O, Horsley A. Combining patient-specific airway models with acinar asymmetry in simulations of multiple breath washout (MBW). European Respiratory Society Meeting (2019). 

Foy BH, Gonem S, Brightling C, Siddiqui S, Kay D. Modeling the effect of gravity on inert-gas washout outputs. Physiological Reports (2018).

Foy BH, Kay D. Sacin responds to total compliance heterogeneity, and is less sensitive to regionalisation than scond. American Thoracic Society Congress (2018).

Foy BH, Bell A, Siddiqui S, Kay D. Low frequency lung resistance is a global bronchoconstriction detection measure, but is still sensitive to small airways disease. American Thoracic Society Congress (2018).

Foy BH, Kay D. A computational comparison of the multiple-breath washout and forced oscillation technique as markers of bronchoconstriction. Respiratory Physiology & Neurobiology (2017).

Foy BH, Bordas R, Kay D. Modeling responses of the inert-gas washout and MRI to bronchoconstriction. Respiratory Physiology & Neurobiology (2017).

Soares M, Owers-Bradley J, Foy BH, et al. The evaluation of frequency dependence of resistance using a patient-specific 3D printed airway model and computational simulation. European Respiratory Society Congress (2017).

Foy BH, Kay D. Inert-gas washout and forced oscillation technique show sensitivity to the degree of regionalisation of bronchoconstriction. American Thoracic Society Congress (2017)

Foy BH, Perre P, Turner I. The Meshfree Finite Volume Method, with application to multi-phase porous media models. Journal of Computational Physics (2017).

WBC_pipeline
A computer vision pipeline for WBC detection

temp.png
Simulated lung ventilation maps in various postures

hba1c_comp
Sketch of hemoglobin glycation in the bloodstream

3D-Printed-Airway2
A 3D printed lung (first 7 generations)

temp
Schematic for capillary blood flow model

2D-Nonlin-comb
2D Fisher equation solved with the MFVM


Simulation of rapid breathing in a virtual lung

Recent Seminars/Talks
A combined computational-clinical approach to understand pulmonary function test sensitivity. BWH, Applied Chest Imaging Laboratory. Feb 2020.

Estimating the age of red blood cells through mathematical simulation: a validated, population dynamics approach. Joint Mathematical Meetings Conference. Jan 2020.

Linking preoperative risk to postoperative outcomes using routine measurements. MIT, Computational Medicine Group. Dec 2019.

Classifying inflammatory response using blood count trajectories and morphology. MGH, Cardiac Surgery Division. June 2019.

RAIL: A model for social impact driven machine learning. Bayesian and Big Data for Social Good Conference. Nov 2018. (Joint presentation with Logan Graham).

A computational framework for simulating the human pulmonary system. QUT, School of Mathematical Sciences. Oct 2018.

Peer Review

I have acted as a reviewer for the following journals:

Annals of Internal Medicine (marked as exceptional reviewer)
American Journal of Respiratory and Critical Care Medicine
Respiratory Physiology & Neurobiology
Journal of Asthma
Journal of Computational Physics
Journal of Mathematical Biology
Medical and Biological Engineering and Computing
Iranian Journal of Science and Technology – Transactions of Civil Engineering