I use mathematics, programming and machine learning to explore mechanistic systems.
In the past I ran an AI research consultancy. We’ve applied machine learning to solve problems in healthcare, digital humanities, energy and social services. You can read about our work here.
Systems medicine papers (published and upcoming)
A complete and computationally tractable model of the pulmonary system. Journal of Computational Physics (undergoing revisions).
Lung computational models provide unique insights into the clinical role of the small airways in asthma. American Journal of Respiratory and Critical Care Medicine (undergoing revisions).
Characterising the role of the small airways in asthma using low frequency forced oscillations during tidal breathing. Science Translation Medicine (under review).
Unraveling disease pathophysiology with mathematical modeling. Annals of Pathophysiology (Invited review paper, under review).
Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma. Journal of Allergy and Clinical Immunology (2019). Link
Modelling the effect of gravity on inert-gas washout outputs. Physiological Reports (2018). Link
A computational comparison of the multiple-breath washout and forced oscillation technique as markers of bronchoconstriction. Respiratory Physiology & Neurobiology (2017). Link
Modeling responses of the inert-gas washout and MRI to bronchoconstriction. Respiratory Physiology & Neurobiology (2017). Link
Travelling waves for a velocity-jump model of cell migration and proliferation. Mathematical Biosciences (2013). Link
Systems medicine conference papers
Sacin responds to total compliance heterogeneity, and is less sensitive to regionalisation than scond. American Thoracic Society Congress (2018).
Low frequency lung resistance is a global bronchoconstriction detection measure, but is still sensitive to small airways disease. American Thoracic Society Congress (2018).
The evaluation of frequency dependence of resistance using a patient-specific 3D printed airway model and computational simulation. European Respiratory Society Congress (2017).
Inert-gas washout and forced oscillation technique show sensitivity to the degree of regionalisation of bronchoconstriction. American Thoracic Society Congress (2017). Link
Machine learning papers (upcoming)
A deep neural network architecture for reconstructing missing words in ancient Greek inscriptions. Digital Humanities Quarterly (in writing).
Predicting pediatric sleep apnea with machine learning: A proof of concept on 456 patients. Journal of Sleep (in writing).
Numerical analysis, and other modelling papers (published and upcoming)
An efficient mesh-free scheme for simulating high-dimensional conservation problems (in writing).
The Meshfree Finite Volume Method, with application to multi-phase porous media models. Journal of Computational Physics (2017). Link
Structural modelling of deformable screens for large door openings. Australian and New Zealand Industrial and Applied Mathematics Journal (2016). Link