We use physics-based mathematical models to simulate airflow, blood flow and gas transfer within the human pulmonary system. These models are simulated upon patient-based virtual lung and vascular structures, generated from computed tomography scans. Models have been validated experimentally (using 3D printed lungs) and clinically.
We use these models to analyse how structural changes to pulmonary morphology generates ventilation heterogeneity, affects oxygen delivery, and alters patient quality of life. We also use these models to better quantify how different types of lung disease are reflected in pulmonary function test outputs. Below are some key publications in this theme (click image to access paper). A full list of publications can be found here.
Some Upcoming Studies
Analysing contributions of airway asymmetry towards generation of flow sequencing.
Investigation of oxygen saturation levels under increasing vascular obliteration.
Phenotyping patients with COPD based on morphologic features of the airways.
Increased ventilation heterogeneity in asthma can be attributed to the proximal bronchioles.
European Respiratory Journal. 2020.
Lung computational models and the role of the small airways in asthma
American Journal of Respiratory and Critical Care Medicine. 2019.
Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma.
Journal of Allergy and Clinical Immunology. 2019.