We use physics-based mathematical models to simulate airflow, blood flow and gas transfer within the human pulmonary system. We use these models to analyze structure-function relationships in the lungs, and morphologic influences on clinical tests of lung function.
Below are some key publications in this theme (click image to access paper). A full list of publications can be found here.
Some Upcoming Studies
Analysing contributions of vascular morphology towards carbon monoxide uptake.
Voxel analysis of lung images reveals structural determinants of ventilation heterogeneity
In asthma positive phase-III slopes results from structural heterogeneity of the bronchial tree.
Journal of Applied Physiology. 2022.
Increased ventilation heterogeneity in asthma can be attributed to the proximal bronchioles.
European Respiratory Journal. 2020.
Lung computational models and the role of the small airways in asthma
American Journal of Respiratory and Critical Care Medicine. 2019.
Functional CT imaging for identification of the spatial determinants of small-airways disease in adults with asthma.
Journal of Allergy and Clinical Immunology. 2019.