We use computational techniques and experimental analysis to explore how the hematologic and cardiovascular systems respond to acute and chronic inflammatory pressure (ischemia, infection, trauma, etc.)
Below are some key publications in this theme (click image to access paper). A full list of publications can be found here.
Some Upcoming Studies
A mathematical model of transfusion dynamics provides novel insights into homeostatic recovery.
Single-cell erythrocyte computer vision analysis provides novel diagnostic, prognostic, and mechanistic insight
Agent-based modelling of red blood cell dynamics predicts emergent hematologic disease.
Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
Nature Communications. 2022.
Association of red blood cell distribution width with mortality risk in hospitalized adults with SARS-CoV-2 infection.
JAMA Network Open. 2020.
Data-driven physiologic thresholds for iron deficiency associated with hematologic decline.
American Journal of Hematology. 2020
Diminished reactive hematopoiesis and cardiac inflammation in a mouse model of recurrent myocardial infarction.
Journal of the American College of Cardiology. 2020
Boston Globe: https://www.bostonglobe.com/2020/09/23/nation/mgh-study-says-routine-blood-test-may-predict-covid-19-hospital-death-risk/
Web MD: https://www.webmd.com/lung/news/20200923/blood-test-could-spot-those-at-highest-risk-for-severe-covid-19?#1